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Local and systemic glucocorticoid metabolism in inflammatory arthritis

BACKGROUND: Isolated, primary synovial fibroblasts generate active glucocorticoids through expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme produces cortisol from inactive cortisone (and prednisolone from prednisone). OBJECTIVE: To determine how intact synovial tissue me...

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Detalles Bibliográficos
Autores principales:	Hardy, R, Rabbitt, E H, Filer, A, Emery, P, Hewison, M, Stewart, P M, Gittoes, N J, Buckley, C D, Raza, K, Cooper, M S
Formato:	Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2008
Materias:	Extended Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564803/ https://www.ncbi.nlm.nih.gov/pubmed/18420938 http://dx.doi.org/10.1136/ard.2008.090662

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