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Local and systemic glucocorticoid metabolism in inflammatory arthritis
BACKGROUND: Isolated, primary synovial fibroblasts generate active glucocorticoids through expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme produces cortisol from inactive cortisone (and prednisolone from prednisone). OBJECTIVE: To determine how intact synovial tissue me...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564803/ https://www.ncbi.nlm.nih.gov/pubmed/18420938 http://dx.doi.org/10.1136/ard.2008.090662 |