Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting enzymes, tryptophan hydroxylase-1 and -2 (TPH1 and TPH2). We used a gene-targeting approach to generate mice with selectiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Savelieva, Katerina V., Zhao, Shulei, Pogorelov, Vladimir M., Rajan, Indrani, Yang, Qi, Cullinan, Emily, Lanthorn, Thomas H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565062/
https://www.ncbi.nlm.nih.gov/pubmed/18923670
http://dx.doi.org/10.1371/journal.pone.0003301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565062/
https://www.ncbi.nlm.nih.gov/pubmed/18923670
http://dx.doi.org/10.1371/journal.pone.0003301

Ejemplares similares