Mutation Rates of TGFBR2 and ACVR2 Coding Microsatellites in Human Cells with Defective DNA Mismatch Repair

Microsatellite instability promotes colonic tumorigenesis through generating frameshift mutations at coding microsatellites of tumor suppressor genes, such as TGFBR2 and ACVR2. As a consequence, signaling through these TGFβ family receptors is abrogated in DNA Mismatch repair (MMR)-deficient tumors....

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Detalles Bibliográficos
Autores principales: Chung, Heekyung, Young, Dennis J., Lopez, Claudia G., Le, Thuy-Anh T., Lee, Jeffrey K., Ream-Robinson, Deena, Huang, Sherry C., Carethers, John M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565065/
https://www.ncbi.nlm.nih.gov/pubmed/18941508
http://dx.doi.org/10.1371/journal.pone.0003463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565065/
https://www.ncbi.nlm.nih.gov/pubmed/18941508
http://dx.doi.org/10.1371/journal.pone.0003463

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