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A haplotype variation affecting the mitochondrial transportation of hMYH protein could be a risk factor for colorectal cancer in Chinese

BACKGROUND: The human MutY homolog (hMYH), a DNA glycolsylase involved in the excision repair of oxidative DNA damage, is currently studied in colorectal cancer (CRC). We previously demonstrated a haplotype variant c.53C>T/c.74G>A of hMYH (T/A) increasing the risk for gastric cancer in Chinese...

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Detalles Bibliográficos
Autores principales: Chen, Huimei, Xu, Lizhi, Qi, Qiufeng, Yao, Yanweng, Zhu, Ming, Wang, Yaping
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565682/
https://www.ncbi.nlm.nih.gov/pubmed/18811933
http://dx.doi.org/10.1186/1471-2407-8-269