Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs

BACKGROUND: Buruli ulcer (BU) is a progressive disease of subcutaneous tissues caused by Mycobacterium ulcerans. The pathology of BU lesions is associated with the local production of a diffusible substance, mycolactone, with cytocidal and immunosuppressive properties. The defective inflammatory res...

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Detalles Bibliográficos
Autores principales: Hong, Hui, Coutanceau, Emmanuelle, Leclerc, Marion, Caleechurn, Laxmee, Leadlay, Peter F., Demangel, Caroline
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565835/
https://www.ncbi.nlm.nih.gov/pubmed/18941518
http://dx.doi.org/10.1371/journal.pntd.0000325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565835/
https://www.ncbi.nlm.nih.gov/pubmed/18941518
http://dx.doi.org/10.1371/journal.pntd.0000325

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