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Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs

BACKGROUND: Buruli ulcer (BU) is a progressive disease of subcutaneous tissues caused by Mycobacterium ulcerans. The pathology of BU lesions is associated with the local production of a diffusible substance, mycolactone, with cytocidal and immunosuppressive properties. The defective inflammatory res...

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Detalles Bibliográficos
Autores principales:	Hong, Hui, Coutanceau, Emmanuelle, Leclerc, Marion, Caleechurn, Laxmee, Leadlay, Peter F., Demangel, Caroline
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565835/ https://www.ncbi.nlm.nih.gov/pubmed/18941518 http://dx.doi.org/10.1371/journal.pntd.0000325

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