Evolutionary Modeling of Rate Shifts Reveals Specificity Determinants in HIV-1 Subtypes

A hallmark of the human immunodeficiency virus 1 (HIV-1) is its rapid rate of evolution within and among its various subtypes. Two complementary hypotheses are suggested to explain the sequence variability among HIV-1 subtypes. The first suggests that the functional constraints at each site remain t...

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Detalles Bibliográficos
Autores principales: Penn, Osnat, Stern, Adi, Rubinstein, Nimrod D., Dutheil, Julien, Bacharach, Eran, Galtier, Nicolas, Pupko, Tal
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566816/
https://www.ncbi.nlm.nih.gov/pubmed/18989394
http://dx.doi.org/10.1371/journal.pcbi.1000214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566816/
https://www.ncbi.nlm.nih.gov/pubmed/18989394
http://dx.doi.org/10.1371/journal.pcbi.1000214

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