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Evolutionary Modeling of Rate Shifts Reveals Specificity Determinants in HIV-1 Subtypes
A hallmark of the human immunodeficiency virus 1 (HIV-1) is its rapid rate of evolution within and among its various subtypes. Two complementary hypotheses are suggested to explain the sequence variability among HIV-1 subtypes. The first suggests that the functional constraints at each site remain t...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566816/ https://www.ncbi.nlm.nih.gov/pubmed/18989394 http://dx.doi.org/10.1371/journal.pcbi.1000214 |