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DNA methylation determination by liquid chromatography–tandem mass spectrometry using novel biosynthetic [U-(15)N]deoxycytidine and [U-(15)N]methyldeoxycytidine internal standards
Methylation of the promoter CpG regions regulates gene transcription by inhibiting transcription factor binding. Deoxycytidine methylation may regulate cell differentiation, while aberrations in the process may be involved in cancer etiology and the development of birth defects (e.g. neural tube def...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566864/ https://www.ncbi.nlm.nih.gov/pubmed/18718928 http://dx.doi.org/10.1093/nar/gkn534 |