Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

Short interfering RNAs (siRNAs) are valuable reagents for sequence-specific inhibition of gene expression via the RNA interference (RNAi) pathway. Although it has been proposed that the relative thermodynamic stability at the 5′-ends of siRNAs plays a crucial role in siRNA strand selection, we demon...

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Detalles Bibliográficos
Autores principales: Sano, Masayuki, Sierant, Malgorzata, Miyagishi, Makoto, Nakanishi, Mahito, Takagi, Yasuomi, Sutou, Shizuyo
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566866/
https://www.ncbi.nlm.nih.gov/pubmed/18782830
http://dx.doi.org/10.1093/nar/gkn584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566866/
https://www.ncbi.nlm.nih.gov/pubmed/18782830
http://dx.doi.org/10.1093/nar/gkn584

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