Mutagenicity of tamoxifen DNA adducts in human endometrial cells and in silico prediction of p53 mutation hotspots

Tamoxifen elevates the risk of endometrial tumours in women and α-(N(2)-deoxyguanosinyl)-tamoxifen adducts are reportedly present in endometrial tissue of patients undergoing therapy. Given the widespread use of tamoxifen there is considerable interest in elucidating the mechanisms underlying treatm...

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Detalles Bibliográficos
Autores principales: Liapis, Evagelos, McLuckie, Keith I.E., Lewis, Paul D., Farmer, Peter B., Brown, Karen
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566887/
https://www.ncbi.nlm.nih.gov/pubmed/18805907
http://dx.doi.org/10.1093/nar/gkn586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566887/
https://www.ncbi.nlm.nih.gov/pubmed/18805907
http://dx.doi.org/10.1093/nar/gkn586

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