14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers

Activation of the tumour suppressor p53 on DNA damage involves post-translational modification by phosphorylation and acetylation. Phosphorylation of certain residues is critical for p53 stabilization and plays an important role in DNA-binding activity. The 14-3-3 family of proteins activates the DN...

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Detalles Bibliográficos
Autores principales: Rajagopalan, Sridharan, Jaulent, Agnes M., Wells, Mark, Veprintsev, Dmitry B., Fersht, Alan R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566891/
https://www.ncbi.nlm.nih.gov/pubmed/18812399
http://dx.doi.org/10.1093/nar/gkn598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566891/
https://www.ncbi.nlm.nih.gov/pubmed/18812399
http://dx.doi.org/10.1093/nar/gkn598

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