p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours

The MDM2 gene is amplified and/or overexpressed in about 10% of glioblastomas and constitutes one of a number of ways the p53 pathway is disrupted in these tumours. MDM2 encodes a nuclear phosphoprotein that regulates several cell proteins by binding and/or ubiquitinating them, with p53 being a well...

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Detalles Bibliográficos
Autores principales: Dimitriadi, M, Poulogiannis, G, Liu, L, Bäcklund, L M, Pearson, D M, Ichimura, K, Collins, V P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567066/
https://www.ncbi.nlm.nih.gov/pubmed/18781178
http://dx.doi.org/10.1038/sj.bjc.6604643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567066/
https://www.ncbi.nlm.nih.gov/pubmed/18781178
http://dx.doi.org/10.1038/sj.bjc.6604643

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