Cargando…

p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours

The MDM2 gene is amplified and/or overexpressed in about 10% of glioblastomas and constitutes one of a number of ways the p53 pathway is disrupted in these tumours. MDM2 encodes a nuclear phosphoprotein that regulates several cell proteins by binding and/or ubiquitinating them, with p53 being a well...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dimitriadi, M, Poulogiannis, G, Liu, L, Bäcklund, L M, Pearson, D M, Ichimura, K, Collins, V P
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2008
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567066/ https://www.ncbi.nlm.nih.gov/pubmed/18781178 http://dx.doi.org/10.1038/sj.bjc.6604643

Ejemplares similares

MDM2 is an important prognostic and predictive factor for platin–pemetrexed therapy in malignant pleural mesotheliomas and deregulation of P14/ARF (encoded by CDKN2A) seems to contribute to an MDM2-driven inactivation of P53
por: Walter, R F H, et al.
Publicado: (2015)

Co-targeting of FAK and MDM2 triggers additive anti-proliferative effects in mesothelioma via a coordinated reactivation of p53
por: Ou, Wen-Bin, et al.
Publicado: (2016)

Δ133p53 is an independent prognostic marker in p53 mutant advanced serous ovarian cancer
por: Hofstetter, G, et al.
Publicado: (2011)

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia
por: Groves, M J, et al.
Publicado: (2013)

Mutations in Rb1 pathway-related genes are associated with poor prognosis in Anaplastic Astrocytomas
por: Bäcklund, L M, et al.
Publicado: (2005)

MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways
por: Wu, N, et al.
Publicado: (2013)

Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule
por: Grinkevich, Vera V., et al.
Publicado: (2022)

Stabilisation of p53 enhances reovirus-induced apoptosis and virus spread through p53-dependent NF-κB activation
por: Pan, D, et al.
Publicado: (2011)

Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation
por: van Miltenburg, M H A M, et al.
Publicado: (2014)

The status of CDKN2A alpha (p16(INK4A)) and beta (p14(ARF)) transcripts in thyroid tumour progression
por: Ferru, A, et al.
Publicado: (2006)

p53 immunodetection of liquid-based processed urinary samples helps to identify bladder tumours with a higher risk of progression
por: Piaton, E, et al.
Publicado: (2005)

The predictive value of molecular markers (p53, EGFR, ATM, CHK2) in multimodally treated squamous cell carcinoma of the oesophagus
por: Sarbia, M, et al.
Publicado: (2007)

Mutant p53 mediates survival of breast cancer cells
por: Lim, L Y, et al.
Publicado: (2009)

p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma
por: Awais, Raheela, et al.
Publicado: (2016)

TIGAR induces p53-mediated cell-cycle arrest by regulation of RB–E2F1 complex
por: Madan, E, et al.
Publicado: (2012)

Tumour-suppressive miRNA-26a-5p and miR-26b-5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer
por: Miyamoto, K, et al.
Publicado: (2016)

Modest effect of p53, EGFR and HER-2/neu on prognosis in epithelial ovarian cancer: a meta-analysis
por: de Graeff, P, et al.
Publicado: (2009)

High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment
por: Ma, G-F, et al.
Publicado: (2014)

A truncated form of CD9-partner 1 (CD9P-1), GS-168AT2, potently inhibits in vivo tumour-induced angiogenesis and tumour growth
por: Colin, S, et al.
Publicado: (2011)

Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review
por: Grønhøj Larsen, C, et al.
Publicado: (2014)

CD9P-1 expression correlates with the metastatic status of lung cancer, and a truncated form of CD9P-1, GS-168AT2, inhibits in vivo tumour growth
por: Guilmain, W, et al.
Publicado: (2011)

Immunostaining of thymidylate synthase and p53 for predicting chemoresistance to S-1/cisplatin in gastric cancer
por: Kamoshida, S, et al.
Publicado: (2007)

The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC
por: Voorneveld, P W, et al.
Publicado: (2015)

MDM2 promotes epithelial–mesenchymal transition and metastasis of ovarian cancer SKOV3 cells
por: Chen, Ying, et al.
Publicado: (2017)

CD8+ lymphocytes/ tumour-budding index: an independent prognostic factor representing a ‘pro-/anti-tumour’ approach to tumour host interaction in colorectal cancer
por: Lugli, A, et al.
Publicado: (2009)

Independent and functional validation of a multi-tumour-type proliferation signature
por: Starmans, M H W, et al.
Publicado: (2012)

Tumour-suppressive microRNA-144-5p directly targets CCNE1/2 as potential prognostic markers in bladder cancer
por: Matsushita, R, et al.
Publicado: (2015)

Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma
por: Aryee, D N T, et al.
Publicado: (2013)

The proportion of tumour cells is an independent predictor for survival in colorectal cancer patients
por: West, N P, et al.
Publicado: (2010)

Tumour morphology predicts PALB2 germline mutation status
por: Teo, Z L, et al.
Publicado: (2013)

Factors influencing p53 expression in ovarian cancer as a biomarker of clinical outcome in multicentre studies
por: de Graeff, P, et al.
Publicado: (2006)

Prediction of outcome of early ER+ breast cancer is improved using a biomarker panel, which includes Ki-67 and p53
por: Millar, E K A, et al.
Publicado: (2011)

Mdmx promotes genomic instability independent of p53 and Mdm2
por: Carrillo, Alexia M., et al.
Publicado: (2014)

Expression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach
por: Yoshii, M, et al.
Publicado: (2012)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas
por: Bain, G H, et al.
Publicado: (2014)

Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX
por: Nehls, O, et al.
Publicado: (2007)

miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop
por: Zhang, Y, et al.
Publicado: (2015)

Study of p53 gene alteration as a biomarker to evaluate the malignant risk of Lugol-unstained lesion with non-dysplasia in the oesophagus
por: Kaneko, K, et al.
Publicado: (2007)

Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype
por: Barathova, M, et al.
Publicado: (2008)

DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer
por: Cui, T, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_h0su2difqf10tgd8v96s7d313q