Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes

Activity-dependent secretion of brain-derived neurotrophic factor (BDNF) is thought to enhance synaptic plasticity, but the mechanisms controlling extracellular availability and clearance of secreted BDNF are poorly understood. We show that BDNF is secreted in its precursor form (pro-BDNF) and is th...

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Detalles Bibliográficos
Autores principales: Bergami, Matteo, Santi, Spartaco, Formaggio, Elena, Cagnoli, Cinzia, Verderio, Claudia, Blum, Robert, Berninger, Benedikt, Matteoli, Michela, Canossa, Marco
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568011/
https://www.ncbi.nlm.nih.gov/pubmed/18852301
http://dx.doi.org/10.1083/jcb.200806137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568011/
https://www.ncbi.nlm.nih.gov/pubmed/18852301
http://dx.doi.org/10.1083/jcb.200806137

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