Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway

Failure to stabilize and properly process stalled replication forks results in chromosome instability, which is a hallmark of cancer cells and several human genetic conditions that are characterized by cancer predisposition. Loss of WRN, a RecQ-like enzyme mutated in the cancer-prone disease Werner...

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Detalles Bibliográficos
Autores principales: Franchitto, Annapaola, Pirzio, Livia Maria, Prosperi, Ennio, Sapora, Orazio, Bignami, Margherita, Pichierri, Pietro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568021/
https://www.ncbi.nlm.nih.gov/pubmed/18852298
http://dx.doi.org/10.1083/jcb.200803173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568021/
https://www.ncbi.nlm.nih.gov/pubmed/18852298
http://dx.doi.org/10.1083/jcb.200803173

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