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Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway
Failure to stabilize and properly process stalled replication forks results in chromosome instability, which is a hallmark of cancer cells and several human genetic conditions that are characterized by cancer predisposition. Loss of WRN, a RecQ-like enzyme mutated in the cancer-prone disease Werner...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568021/ https://www.ncbi.nlm.nih.gov/pubmed/18852298 http://dx.doi.org/10.1083/jcb.200803173 |