Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

Survivin is a key cellular protein thought to function in apoptotic regulation, mitotic progression, or possibly both. In this study, we describe the isolation of two conditional knockouts of the survivin gene in chicken DT40 cells. DT40 cells lacking Survivin die in interphase after failing to comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Yue, Zuojun, Carvalho, Ana, Xu, Zhenjie, Yuan, Xuemei, Cardinale, Stefano, Ribeiro, Susana, Lai, Fan, Ogawa, Hiromi, Gudmundsdottir, Elisabet, Gassmann, Reto, Morrison, Ciaran G., Ruchaud, Sandrine, Earnshaw, William C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568024/
https://www.ncbi.nlm.nih.gov/pubmed/18936249
http://dx.doi.org/10.1083/jcb.200806118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568024/
https://www.ncbi.nlm.nih.gov/pubmed/18936249
http://dx.doi.org/10.1083/jcb.200806118

Ejemplares similares