Serpins show structural basis for oligomer toxicity and amyloid ubiquity

Many disorders, including Alzheimer’s, the prion encephalopathies and other neurodegenerative diseases, result from aberrant protein aggregation. Surprisingly, cellular toxicity is often due not to the highly-ordered aggregates but to the oligomers that precede their formation. Using serpins as a pa...

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Detalles Bibliográficos
Autores principales: Carrell, Robin W., Mushunje, Alec, Zhou, Aiwu
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568812/
https://www.ncbi.nlm.nih.gov/pubmed/18573252
http://dx.doi.org/10.1016/j.febslet.2008.06.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568812/
https://www.ncbi.nlm.nih.gov/pubmed/18573252
http://dx.doi.org/10.1016/j.febslet.2008.06.021

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