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Serpins show structural basis for oligomer toxicity and amyloid ubiquity
Many disorders, including Alzheimer’s, the prion encephalopathies and other neurodegenerative diseases, result from aberrant protein aggregation. Surprisingly, cellular toxicity is often due not to the highly-ordered aggregates but to the oligomers that precede their formation. Using serpins as a pa...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science B.V
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568812/ https://www.ncbi.nlm.nih.gov/pubmed/18573252 http://dx.doi.org/10.1016/j.febslet.2008.06.021 |