Chemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell Death

Streptozotocin is a natural product that selectively kills insulin-secreting β cells, and is widely used to generate mouse models of diabetes or treat pancreatic tumors. Several studies suggest that streptozotocin toxicity stems from its N-nitrosourea moiety releasing nitric oxide and possessing DNA...

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Detalles Bibliográficos
Autores principales: Pathak, Shalini, Dorfmueller, Helge C., Borodkin, Vladimir S., van Aalten, Daan M.F.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568864/
https://www.ncbi.nlm.nih.gov/pubmed/18721751
http://dx.doi.org/10.1016/j.chembiol.2008.06.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568864/
https://www.ncbi.nlm.nih.gov/pubmed/18721751
http://dx.doi.org/10.1016/j.chembiol.2008.06.010

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