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Chemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell Death
Streptozotocin is a natural product that selectively kills insulin-secreting β cells, and is widely used to generate mouse models of diabetes or treat pancreatic tumors. Several studies suggest that streptozotocin toxicity stems from its N-nitrosourea moiety releasing nitric oxide and possessing DNA...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568864/ https://www.ncbi.nlm.nih.gov/pubmed/18721751 http://dx.doi.org/10.1016/j.chembiol.2008.06.010 |