Loss of a Mycobacterial Gene Encoding a Reductase Leads to an Altered Cell Wall Containing β-oxo- Mycolic Acid Analogs and Accumulation of Ketones

Mycolic acids are essential components of the mycobacterial cell wall. In this study, we show that a gene encoding a reductase involved in the final step of mycolic acid biosynthesis can be deleted in Mycobacterium smegmatis without affecting cell viability. Deletion of MSMEG4722 (ortholog of Mycoba...

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Detalles Bibliográficos
Autores principales: Bhatt, Apoorva, Brown, Alistair K., Singh, Albel, Minnikin, David E., Besra, Gurdyal S.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568869/
https://www.ncbi.nlm.nih.gov/pubmed/18804030
http://dx.doi.org/10.1016/j.chembiol.2008.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568869/
https://www.ncbi.nlm.nih.gov/pubmed/18804030
http://dx.doi.org/10.1016/j.chembiol.2008.07.007

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