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Loss of a Mycobacterial Gene Encoding a Reductase Leads to an Altered Cell Wall Containing β-oxo- Mycolic Acid Analogs and Accumulation of Ketones
Mycolic acids are essential components of the mycobacterial cell wall. In this study, we show that a gene encoding a reductase involved in the final step of mycolic acid biosynthesis can be deleted in Mycobacterium smegmatis without affecting cell viability. Deletion of MSMEG4722 (ortholog of Mycoba...
Autores principales: | Bhatt, Apoorva, Brown, Alistair K., Singh, Albel, Minnikin, David E., Besra, Gurdyal S. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568869/ https://www.ncbi.nlm.nih.gov/pubmed/18804030 http://dx.doi.org/10.1016/j.chembiol.2008.07.007 |
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