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CYP2C19 pharmacogenetics in advanced cancer: compromised function independent of genotype
CYP2C19 is a drug-metabolising enzyme involved in the metabolism of a number of chemotherapeutic agents including cyclophosphamide. Variants of the CYP2C19 gene result in a loss of function polymorphism, which affects approximately 3% of the Caucasian population. These individuals are poor metabolis...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570511/ https://www.ncbi.nlm.nih.gov/pubmed/18854824 http://dx.doi.org/10.1038/sj.bjc.6604699 |