Histidine Residues at the Active Site of the Pasteurella multocida Toxin

We have investigated histidine residues near the active site of the mitogenic Pasteurella multocida toxin. Mutation of H1202 or H1228 had little effect, while the effect of mutation on H1223 depended on the amino acid substituted. Mutation of H1205 caused complete loss of activity, indicating its im...

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Detalles Bibliográficos
Autores principales: Pullinger, Gillian D, Lax, Alistair J
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570546/
https://www.ncbi.nlm.nih.gov/pubmed/18949067
http://dx.doi.org/10.2174/1874091X00701010007
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author Pullinger, Gillian D
Lax, Alistair J
author_facet Pullinger, Gillian D
Lax, Alistair J
author_sort Pullinger, Gillian D
collection PubMed
description We have investigated histidine residues near the active site of the mitogenic Pasteurella multocida toxin. Mutation of H1202 or H1228 had little effect, while the effect of mutation on H1223 depended on the amino acid substituted. Mutation of H1205 caused complete loss of activity, indicating its importance in PMT activity.
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spelling pubmed-25705462008-10-23 Histidine Residues at the Active Site of the Pasteurella multocida Toxin Pullinger, Gillian D Lax, Alistair J Open Biochem J Article We have investigated histidine residues near the active site of the mitogenic Pasteurella multocida toxin. Mutation of H1202 or H1228 had little effect, while the effect of mutation on H1223 depended on the amino acid substituted. Mutation of H1205 caused complete loss of activity, indicating its importance in PMT activity. Bentham Science Publishers Ltd. 2007-06-15 /pmc/articles/PMC2570546/ /pubmed/18949067 http://dx.doi.org/10.2174/1874091X00701010007 Text en 2007 Bentham Science Publishers Ltd
spellingShingle Article
Pullinger, Gillian D
Lax, Alistair J
Histidine Residues at the Active Site of the Pasteurella multocida Toxin
title Histidine Residues at the Active Site of the Pasteurella multocida Toxin
title_full Histidine Residues at the Active Site of the Pasteurella multocida Toxin
title_fullStr Histidine Residues at the Active Site of the Pasteurella multocida Toxin
title_full_unstemmed Histidine Residues at the Active Site of the Pasteurella multocida Toxin
title_short Histidine Residues at the Active Site of the Pasteurella multocida Toxin
title_sort histidine residues at the active site of the pasteurella multocida toxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570546/
https://www.ncbi.nlm.nih.gov/pubmed/18949067
http://dx.doi.org/10.2174/1874091X00701010007
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