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Mutation of the Zebrafish Nucleoporin elys Sensitizes Tissue Progenitors to Replication Stress
The recessive lethal mutation flotte lotte (flo) disrupts development of the zebrafish digestive system and other tissues. We show that flo encodes the ortholog of Mel-28/Elys, a highly conserved gene that has been shown to be required for nuclear integrity in worms and nuclear pore complex (NPC) as...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570612/ https://www.ncbi.nlm.nih.gov/pubmed/18974873 http://dx.doi.org/10.1371/journal.pgen.1000240 |