A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition

Cysteine proteases of the Clan CA (papain) family are the predominant protease group in primitive invertebrates. Cysteine protease inhibitors arrest infection by the protozoan parasite, Trypanosoma brucei. RNA interference studies implicated a cathepsin B-like protease, tbcatB, as a key inhibitor ta...

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Detalles Bibliográficos
Autores principales: O'Brien, Theresa C., Mackey, Zachary B., Fetter, Richard D., Choe, Youngchool, O'Donoghue, Anthony J., Zhou, Min, Craik, Charles S., Caffrey, Conor R., McKerrow, James H.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Enzyme Catalysis and Regulation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570886/
https://www.ncbi.nlm.nih.gov/pubmed/18701454
http://dx.doi.org/10.1074/jbc.M805824200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570886/
https://www.ncbi.nlm.nih.gov/pubmed/18701454
http://dx.doi.org/10.1074/jbc.M805824200

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