Regulation of class switch recombination and somatic mutation by AID phosphorylation

Activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-s...

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Detalles Bibliográficos
Autores principales: McBride, Kevin M., Gazumyan, Anna, Woo, Eileen M., Schwickert, Tanja A., Chait, Brian T., Nussenzweig, Michel C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571933/
https://www.ncbi.nlm.nih.gov/pubmed/18838546
http://dx.doi.org/10.1084/jem.20081319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571933/
https://www.ncbi.nlm.nih.gov/pubmed/18838546
http://dx.doi.org/10.1084/jem.20081319

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