Cargando…

Regulation of class switch recombination and somatic mutation by AID phosphorylation

Activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-s...

Descripción completa

Detalles Bibliográficos
Autores principales:	McBride, Kevin M., Gazumyan, Anna, Woo, Eileen M., Schwickert, Tanja A., Chait, Brian T., Nussenzweig, Michel C.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571933/ https://www.ncbi.nlm.nih.gov/pubmed/18838546 http://dx.doi.org/10.1084/jem.20081319

Ejemplares similares

AID function in somatic hypermutation and class switch recombination: AID function in somatic hypermutation and class switch recombination
por: Yu, Kefei
Publicado: (2022)

AID from bony fish catalyzes class switch recombination
por: Barreto, Vasco M., et al.
Publicado: (2005)

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
por: Bothmer, Anne, et al.
Publicado: (2010)

The Function of AID in Somatic Mutation and Class Switch Recombination: Upstream or Downstream of DNA Breaks
por: Chua, Katrin F., et al.
Publicado: (2002)

An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex
por: Kracker, Sven, et al.
Publicado: (2015)

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching
por: Bothmer, Anne, et al.
Publicado: (2013)

H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation
por: Reina-San-Martin, Bernardo, et al.
Publicado: (2003)

The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination
por: Delgado-Benito, Verónica, et al.
Publicado: (2018)

53BP1 is required for class switch recombination
por: Ward, Irene M., et al.
Publicado: (2004)

HoxC4 binds to the Aicda promoter to induce AID expression, class switch DNA recombination and somatic hypermutation
por: Park, Seok-Rae, et al.
Publicado: (2009)

Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase
por: McBride, Kevin M., et al.
Publicado: (2004)

Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association
por: Mu, Yunxiang, et al.
Publicado: (2018)

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
por: Pan-Hammarström, Qiang, et al.
Publicado: (2006)

The Fanconi Anemia Core Complex Is Dispensable during Somatic Hypermutation and Class Switch Recombination
por: Krijger, Peter H. L., et al.
Publicado: (2010)

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination
por: Jeevan-Raj, Beena Patricia, et al.
Publicado: (2011)

Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region: Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation
por: Nagaoka, Hitoshi, et al.
Publicado: (2002)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2010)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2013)

AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination
por: Vaidyanathan, Bharat, et al.
Publicado: (2014)

A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination
por: Martomo, Stella A., et al.
Publicado: (2004)

Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination
por: Kadungure, Tatenda, et al.
Publicado: (2015)

ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions
por: Reina-San-Martin, Bernardo, et al.
Publicado: (2004)

Heavy-chain class switch does not terminate somatic mutation
Publicado: (1990)

Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
por: Dong, Junchao, et al.
Publicado: (2015)

Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
por: Martin, Alberto, et al.
Publicado: (2003)

Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination
por: He, Yafeng, et al.
Publicado: (2020)

Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance
por: Takata, Kei-ichi, et al.
Publicado: (2017)

Quantitative Regulation of Class Switch Recombination by Switch Region Transcription
por: Lee, Chung-Gi, et al.
Publicado: (2001)

Immunoglobulin class-switch recombination deficiencies
por: Durandy, Anne, et al.
Publicado: (2012)

14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′-rich switch regions for class switch recombination
por: Xu, Zhenming, et al.
Publicado: (2010)

Germinal center reutilization by newly activated B cells
por: Schwickert, Tanja A., et al.
Publicado: (2009)

B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation
por: Stoler-Barak, Liat, et al.
Publicado: (2023)

Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells
por: Nguyen, Thuy Vy, et al.
Publicado: (2014)

Epigenetic Codes Programing Class Switch Recombination
por: Vaidyanathan, Bharat, et al.
Publicado: (2015)

NME proteins regulate class switch recombination
por: Zheng, Simin, et al.
Publicado: (2018)

Making ends meet in class switch recombination
por: Wu, Lizhen, et al.
Publicado: (2020)

Processing of Switch Transcripts Is Required for Targeting of Antibody Class Switch Recombination
por: Hein, Katharina, et al.
Publicado: (1998)

Igβ tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization
por: Gazumyan, Anna, et al.
Publicado: (2006)

The Interaction between AID and CIB1 Is Nonessential for Antibody Gene Diversification by Gene Conversion or Class Switch Recombination
por: Demorest, Zachary L., et al.
Publicado: (2010)

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation
por: Spanjaard, Aldo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gvcvrmuo6l3p2kkgjvek9psctp