hERG Gating Microdomains Defined by S6 Mutagenesis and Molecular Modeling

Human ether-à-go-go–related gene (hERG) channels mediate cardiac repolarization and bind drugs that can cause acquired long QT syndrome and life-threatening arrhythmias. Drugs bind in the vestibule formed by the S6 transmembrane domain, which also contains the activation gate that traps drugs in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Wynia-Smith, Sarah L., Gillian-Daniel, Anne Lynn, Satyshur, Kenneth A., Robertson, Gail A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571969/
https://www.ncbi.nlm.nih.gov/pubmed/18955593
http://dx.doi.org/10.1085/jgp.200810083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571969/
https://www.ncbi.nlm.nih.gov/pubmed/18955593
http://dx.doi.org/10.1085/jgp.200810083

Ejemplares similares