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hERG Gating Microdomains Defined by S6 Mutagenesis and Molecular Modeling

Human ether-à-go-go–related gene (hERG) channels mediate cardiac repolarization and bind drugs that can cause acquired long QT syndrome and life-threatening arrhythmias. Drugs bind in the vestibule formed by the S6 transmembrane domain, which also contains the activation gate that traps drugs in the...

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Detalles Bibliográficos
Autores principales:	Wynia-Smith, Sarah L., Gillian-Daniel, Anne Lynn, Satyshur, Kenneth A., Robertson, Gail A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571969/ https://www.ncbi.nlm.nih.gov/pubmed/18955593 http://dx.doi.org/10.1085/jgp.200810083

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