Cargando…

Properties of the Inner Pore Region of TRPV1 Channels Revealed by Block with Quaternary Ammoniums

The transient receptor potential vanilloid 1 (TRPV1) nonselective cationic channel is a polymodal receptor that activates in response to a wide variety of stimuli. To date, little structural information about this channel is available. Here, we used quaternary ammonium ions (QAs) of different sizes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jara-Oseguera, Andrés, Llorente, Itzel, Rosenbaum, Tamara, Islas, León D.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571972/ https://www.ncbi.nlm.nih.gov/pubmed/18955595 http://dx.doi.org/10.1085/jgp.200810051

Ejemplares similares

Unique Inner Pore Properties of BK Channels Revealed by Quaternary Ammonium Block
por: Li, Weiyan, et al.
Publicado: (2004)

Different agonists induce distinct single-channel conductance states in TRPV1 channels
por: Canul-Sánchez, Jesús Aldair, et al.
Publicado: (2018)

Heat activation is intrinsic to the pore domain of TRPV1
por: Zhang, Feng, et al.
Publicado: (2018)

Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands
por: Benítez-Angeles, Miguel, et al.
Publicado: (2022)

The Inner Quaternary Ammonium Ion Receptor in Potassium Channels of the Node of Ranvier
por: Armstrong, Clay M., et al.
Publicado: (1972)

Kinetics of Inward-Rectifier K(+) Channel Block by Quaternary Alkylammonium Ions: Dimension and Properties of the Inner Pore
por: Guo, Donglin, et al.
Publicado: (2001)

State-independent Block of BK Channels by an Intracellular Quaternary Ammonium
por: Wilkens, Christina M., et al.
Publicado: (2006)

The ion selectivity filter is not an activation gate in TRPV1-3 channels
por: Jara-Oseguera, Andrés, et al.
Publicado: (2019)

An external sodium ion binding site controls allosteric gating in TRPV1 channels
por: Jara-Oseguera, Andres, et al.
Publicado: (2016)

Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
por: Morales-Lázaro, Sara L., et al.
Publicado: (2016)

Cannabidiol sensitizes TRPV2 channels to activation by 2-APB
por: Gochman, Aaron, et al.
Publicado: (2023)

Interaction between Quaternary Ammonium Ions in the Pore of Potassium Channels: Evidence against an Electrostatic Repulsion Mechanism
por: Thompson, Jill, et al.
Publicado: (2000)

Access of Quaternary Ammonium Blockers to the Internal Pore of Cyclic Nucleotide-gated Channels: Implications for the Location of the Gate
por: Contreras, Jorge E., et al.
Publicado: (2006)

Engineering vanilloid-sensitivity into the rat TRPV2 channel
por: Zhang, Feng, et al.
Publicado: (2016)

Irreversible temperature gating in trpv1 sheds light on channel activation
por: Sánchez-Moreno, Ana, et al.
Publicado: (2018)

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1
por: Rapedius, Markus, et al.
Publicado: (2012)

Kinetics of Tethering Quaternary Ammonium Compounds to K(+) Channels
por: Blaustein, Robert O.
Publicado: (2002)

Light-Sensitive Open Channel Block of Ionotropic Glutamate Receptors by Quaternary Ammonium Azobenzene Derivatives
por: Nikolaev, Maxim, et al.
Publicado: (2023)

Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity
por: Zhang, Feng, et al.
Publicado: (2019)

State-dependent Block of CNG Channels by Dequalinium
por: Rosenbaum, Tamara, et al.
Publicado: (2004)

Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions
por: Fineberg, Jeffrey D., et al.
Publicado: (2016)

Electrostatics and the Gating Pore of Shaker Potassium Channels
por: Islas, Leon D., et al.
Publicado: (2001)

Block of outward current in cardiac purkinje fibers by injection of quaternary ammonium ions
por: Kass, RS, et al.
Publicado: (1982)

Quaternary ammonium compounds as structural probes of single batrachotoxin-activated Na+ channels
Publicado: (1991)

Delimiting the Binding Site for Quaternary Ammonium Lidocaine Derivatives in the Acetylcholine Receptor Channel
por: Pascual, Juan M., et al.
Publicado: (1998)

Bis-quaternary ammonium blockers as structural probes of the sarcoplasmic reticulum K+ channel
Publicado: (1982)

Microwave Synthesis of Quaternary Ammonium Salts
por: Winstead, Angela J., et al.
Publicado: (2008)

Quaternary ammonium compounds in hypersensitivity reactions
por: Peyneau, Marine, et al.
Publicado: (2022)

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin
por: Bae, Chanhyung, et al.
Publicado: (2016)

Confined Dynamics of Water in Transmembrane Pore of TRPV1 Ion Channel
por: Trofimov, Yury A., et al.
Publicado: (2019)

Insight into the Desolvation of Quaternary Ammonium Cation with Acetonitrile as a Solvent in Hydroxyl-Flat Pores: A First-Principles Calculation
por: Liu, Fudong, et al.
Publicado: (2023)

The Use of Quaternary Ammonium to Combat Dental Caries
por: Ge, Yang, et al.
Publicado: (2015)

Biological Activity of Quaternary Ammonium Salts and Their Derivatives
por: Kwaśniewska, Dobrawa, et al.
Publicado: (2020)

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
por: Grandl, Jörg, et al.
Publicado: (2010)

K(V)1.2 channels inactivate through a mechanism similar to C-type inactivation
por: Suárez-Delgado, Esteban, et al.
Publicado: (2020)

TRPV4: A Physio and Pathophysiologically Significant Ion Channel
por: Rosenbaum, Tamara, et al.
Publicado: (2020)

Uptake of Some Quaternary Ammonium Ions by Human Erythrocytes
por: ASKARI, AMIR
Publicado: (1966)

Antimicrobial Polymeric Materials with Quaternary Ammonium and Phosphonium Salts
por: Xue, Yan, et al.
Publicado: (2015)

Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates
por: Dmochowska, Barbara, et al.
Publicado: (2016)

Turbulence and Cavitation Suppression by Quaternary Ammonium Salt Additives
por: Naseri, Homa, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ltbjelegtb5728m8rl4le7g6nl