Growth Arrest of BCR-ABL Positive Cells with a Sequence-Specific Polyamide-Chlorambucil Conjugate

Chronic myeloid leukemia (CML) is characterized by the presence of a constitutively active Abl kinase, which is the product of a chimeric BCR-ABL gene, caused by the genetic translocation known as the Philadelphia chromosome. Imatinib, a selective inhibitor of the Bcr-Abl tyrosine kinase, has signif...

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Detalles Bibliográficos
Autores principales: Chou, C. James, O'Hare, Thomas, Lefebvre, Sophie, Alvarez, David, Tyner, Jeffrey W., Eide, Christopher A., Druker, Brian J., Gottesfeld, Joel M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571993/
https://www.ncbi.nlm.nih.gov/pubmed/18974832
http://dx.doi.org/10.1371/journal.pone.0003593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571993/
https://www.ncbi.nlm.nih.gov/pubmed/18974832
http://dx.doi.org/10.1371/journal.pone.0003593

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