Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells

BACKGROUND: CD147 plays a critical role in the invasive and metastatic activity of hepatocellular carcinoma (HCC) cells by stimulating the surrounding fibroblasts to express matrix metalloproteinases (MMPs). Tumor cells adhesion to extracellular matrix (ECM) proteins is the first step to the tumor m...

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Detalles Bibliográficos
Autores principales: Qian, Ai-Rong, Zhang, Wei, Cao, Jian-Ping, Yang, Peng-Fei, Gao, Xiang, Wang, Zhe, Xu, Hui-Yun, Weng, Yuan-Yuan, Shang, Peng
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572039/
https://www.ncbi.nlm.nih.gov/pubmed/18847500
http://dx.doi.org/10.1186/1756-9966-27-50

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572039/
https://www.ncbi.nlm.nih.gov/pubmed/18847500
http://dx.doi.org/10.1186/1756-9966-27-50

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