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Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway
BACKGROUND: Microglia are macrophage-like cells that constantly sense the microenvironment within the central nervous system (CNS). In the event of neuronal stress or injury, microglial cells rapidly react and change their phenotype. This response may lead to a deleterious type of microglial activat...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572162/ https://www.ncbi.nlm.nih.gov/pubmed/18844999 http://dx.doi.org/10.1186/1742-2094-5-43 |