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A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding

The c-Myb protein is a transcriptional regulator initially identified by homology to the v-Myb oncoprotein, and has since been implicated in human cancer. The most highly conserved portion of the c-Myb protein is the DNA-binding domain which consists of three imperfect repeats. Many other proteins c...

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Detalles Bibliográficos
Autores principales: Ko, Emily Ray, Ko, Dennis, Chen, Carolyn, Lipsick, Joseph S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572630/
https://www.ncbi.nlm.nih.gov/pubmed/18840288
http://dx.doi.org/10.1186/1476-4598-7-77