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Estimation of significance thresholds for genomewide association scans

The question of what significance threshold is appropriate for genomewide association studies is somewhat unresolved. Previous theoretical suggestions have yet to be validated in practice, whereas permutation testing does not resolve a discrepancy between the genomewide multiplicity of the experimen...

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Detalles Bibliográficos
Autores principales: Dudbridge, Frank, Gusnanto, Arief
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573032/
https://www.ncbi.nlm.nih.gov/pubmed/18300295
http://dx.doi.org/10.1002/gepi.20297