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Chronic Antidiabetic Sulfonylureas In Vivo: Reversible Effects on Mouse Pancreatic β-Cells
BACKGROUND: Pancreatic β-cell ATP-sensitive potassium (K(ATP)) channels are critical links between nutrient metabolism and insulin secretion. In humans, reduced or absent β-cell K(ATP) channel activity resulting from loss-of-function K(ATP) mutations induces insulin hypersecretion. Mice with reduced...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573909/ https://www.ncbi.nlm.nih.gov/pubmed/18959471 http://dx.doi.org/10.1371/journal.pmed.0050206 |