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Retinoblastoma Loss Modulates DNA Damage Response Favoring Tumor Progression
Senescence is one of the main barriers against tumor progression. Oncogenic signals in primary cells result in oncogene-induced senescence (OIS), crucial for protection against cancer development. It has been described in premalignant lesions that OIS requires DNA damage response (DDR) activation, s...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573954/ https://www.ncbi.nlm.nih.gov/pubmed/18985151 http://dx.doi.org/10.1371/journal.pone.0003632 |