Retinoblastoma Loss Modulates DNA Damage Response Favoring Tumor Progression

Senescence is one of the main barriers against tumor progression. Oncogenic signals in primary cells result in oncogene-induced senescence (OIS), crucial for protection against cancer development. It has been described in premalignant lesions that OIS requires DNA damage response (DDR) activation, s...

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Detalles Bibliográficos
Autores principales: Seoane, Marcos, Iglesias, Pablo, Gonzalez, Teresa, Dominguez, Fernando, Fraga, Maximo, Aliste, Carlos, Forteza, Jeronimo, Costoya, Jose A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573954/
https://www.ncbi.nlm.nih.gov/pubmed/18985151
http://dx.doi.org/10.1371/journal.pone.0003632

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