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The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1
BACKGROUND: Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims N-terminally extended antigenic peptide precursors down to mature antigenic peptides for presentation by major histocompatibility complex (MHC) class I molecules. ERAP1 has unique properties for an aminopeptidase being able to trim pep...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573961/ https://www.ncbi.nlm.nih.gov/pubmed/18987748 http://dx.doi.org/10.1371/journal.pone.0003658 |