Cargando…

The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1

BACKGROUND: Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims N-terminally extended antigenic peptide precursors down to mature antigenic peptides for presentation by major histocompatibility complex (MHC) class I molecules. ERAP1 has unique properties for an aminopeptidase being able to trim pep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Evnouchidou, Irini, Momburg, Frank, Papakyriakou, Athanasios, Chroni, Angeliki, Leondiadis, Leondios, Chang, Shih-Chung, Goldberg, Alfred L., Stratikos, Efstratios
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573961/ https://www.ncbi.nlm.nih.gov/pubmed/18987748 http://dx.doi.org/10.1371/journal.pone.0003658

Ejemplares similares

Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
por: Papakyriakou, Athanasios, et al.
Publicado: (2022)

Structural Basis For Antigenic Peptide Precursor Processing by the Endoplasmic Reticulum Aminopeptidase ERAP1
por: Nguyen, Tina T., et al.
Publicado: (2011)

The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I
por: Mavridis, George, et al.
Publicado: (2021)

ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing
por: Chen, Hanna, et al.
Publicado: (2016)

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases
por: Papakyriakou, Athanasios, et al.
Publicado: (2017)

Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism
por: Maben, Zachary, et al.
Publicado: (2021)

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia
por: Seamon, Kimberly, et al.
Publicado: (2020)

Author Correction: Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism
por: Maben, Zachary, et al.
Publicado: (2023)

The partial dissociation of MHC class I–bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1
por: Papakyriakou, Athanasios, et al.
Publicado: (2018)

Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase
por: Temponeras, Ioannis, et al.
Publicado: (2021)

ERAP2 Inhibition Induces Cell-Surface Presentation by MOLT-4 Leukemia Cancer Cells of Many Novel and Potentially Antigenic Peptides
por: Temponeras, Ioannis, et al.
Publicado: (2022)

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific
por: Dafnis, Ioannis, et al.
Publicado: (2016)

A novel ERAP2 haplotype structure in a Chilean population: implications for ERAP2 protein expression and preeclampsia risk
por: Vanhille, Derek L, et al.
Publicado: (2013)

A novel ERAP2 haplotype structure in a Chilean population: implications for ERAP2 protein expression and preeclampsia risk
por: Vanhille, Derek L, et al.
Publicado: (2013)

Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia
por: Georgiadou, Dimitra, et al.
Publicado: (2011)

Concerted In Vitro Trimming of Viral HLA-B27-Restricted Ligands by Human ERAP1 and ERAP2 Aminopeptidases
por: Lorente, Elena, et al.
Publicado: (2013)

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29
por: Venema, Wouter J., et al.
Publicado: (2021)

The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central Metabolism
por: Vlastaridis, Panayotis, et al.
Publicado: (2017)

ERAP1 enzyme-mediated trimming and structural analyses of MHC I–bound precursor peptides yield novel insights into antigen processing and presentation
por: Li, Lenong, et al.
Publicado: (2019)

Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese
por: Zhang, Shuqiong, et al.
Publicado: (2020)

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis
por: Camberlein, Virgyl, et al.
Publicado: (2022)

The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease
por: Paladini, Fabiana, et al.
Publicado: (2020)

Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women
por: Ferreira, Leonardo Capistrano, et al.
Publicado: (2021)

The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
por: Martín-Esteban, Adrian, et al.
Publicado: (2022)

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins
por: López de Castro, José A.
Publicado: (2018)

ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19?
por: D’Amico, Silvia, et al.
Publicado: (2021)

Monitoring of Polycyclic Aromatic Hydrocarbon Levels in Mussels (Mytilus galloprovincialis) from Aquaculture Farms in Central Macedonia Region, Greece, Using Gas Chromatography–Tandem Mass Spectrometry Method
por: Grigoriou, Constantina, et al.
Publicado: (2021)

ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han
por: Su, W., et al.
Publicado: (2018)

Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis
por: Kuiper, Jonas J W, et al.
Publicado: (2018)

An Overview on ERAP Roles in Infectious Diseases
por: Saulle, Irma, et al.
Publicado: (2020)

A Role for Naturally Occurring Alleles of Endoplasmic Reticulum Aminopeptidases in Tumor Immunity and Cancer Pre-Disposition
por: Stratikos, Efstratios, et al.
Publicado: (2014)

An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes
por: Paladini, Fabiana, et al.
Publicado: (2018)

Substrate recognition by TRIM and TRIM-like proteins in innate immunity
por: Wang, Hai-Tao, et al.
Publicado: (2021)

The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
por: Mattorre, Benedetta, et al.
Publicado: (2022)

The role of polymorphic ERAP1 in autoinflammatory disease
por: Reeves, Emma, et al.
Publicado: (2018)

The Impact of the ‘Mis-Peptidome’ on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response
por: Tedeschi, Valentina, et al.
Publicado: (2020)

Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein
por: Stamatakis, George, et al.
Publicado: (2021)

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties
por: Hutchinson, Jonathan P., et al.
Publicado: (2021)

The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy
por: Mpakali, Anastasia, et al.
Publicado: (2021)

Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics
por: Yoshimaru, Tetsuro, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hcme6hu54lgsmlebilsdjct4gf