Cargando…

Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3

Inhibitor of apoptosis (IAP) proteins have a crucial role in apoptosis, through negative regulation of caspases in species from fruitflies to mammals. In Caenorhabditis elegans, however, no IAP homolog or caspase inhibitor has been identified, calling into question how the cell-killing caspase CED-3...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geng, Xin, Shi, Yong, Nakagawa, Akihisa, Yoshina, Sawako, Mitani, Shohei, Shi, Yigong, Xue, Ding
Formato:	Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574878/ https://www.ncbi.nlm.nih.gov/pubmed/18776901 http://dx.doi.org/10.1038/nsmb.1488

Ejemplares similares

C. elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells
por: Geng, X, et al.
Publicado: (2009)

Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation
por: Yoshina, Sawako, et al.
Publicado: (2015)

Caenorhabditis elegans ced-3 Caspase Is Required for Asymmetric Divisions That Generate Cells Programmed To Die
por: Mishra, Nikhil, et al.
Publicado: (2018)

Distinct pathways for export of silencing RNA in Caenorhabditis elegans systemic RNAi
por: Yoshida, Keita, et al.
Publicado: (2023)

Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalisation
por: Chen, Yu-Zen, et al.
Publicado: (2013)

Structural insights into CED-3 activation
por: Li, Yini, et al.
Publicado: (2023)

The Core Apoptotic Executioner Proteins CED-3 and CED-4 Promote Initiation of Neuronal Regeneration in Caenorhabditis elegans
por: Pinan-Lucarre, Berangere, et al.
Publicado: (2012)

Mechanistic insights into CED-4-mediated activation of CED-3
por: Huang, Weijiao, et al.
Publicado: (2013)

A Conditional Knockout Toolkit for Caenorhabditis elegans Based on the Cre/loxP Recombination
por: Kage-Nakadai, Eriko, et al.
Publicado: (2014)

Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants
por: Li, Xin, et al.
Publicado: (2013)

Single/low-copy integration of transgenes in Caenorhabditis elegans using an ultraviolet trimethylpsoralen method
por: Kage-Nakadai, Eriko, et al.
Publicado: (2012)

C. elegans EIF-3.K Promotes Programmed Cell Death through CED-3 Caspase
por: Huang, Chun-Yi, et al.
Publicado: (2012)

An atonal homolog, lin-32, regulates hypodermal morphogenesis in Caenorhabditis elegans
por: Hori, Sayaka, et al.
Publicado: (2023)

Locus-specific integration of extrachromosomal transgenes in C. elegans with the CRISPR/Cas9 system
por: Yoshina, Sawako, et al.
Publicado: (2015)

Novel deletion alleles of a C. elegans gene C38D4.9, named as tm4476 and tm4561
por: Yoshina, Sawako, et al.
Publicado: (2017)

Defects in CISD-1, a mitochondrial iron-sulfur protein, lower glucose level and ATP production in Caenorhabditis elegans
por: Hsiung, Kuei-Ching, et al.
Publicado: (2020)

Engineering new balancer chromosomes in C. elegans via CRISPR/Cas9
por: Iwata, Satoru, et al.
Publicado: (2016)

Novel deletion alleles of a C. elegans gene Y73E7A.1, named as tm6429 and tm6475
por: Suehiro, Yuji, et al.
Publicado: (2017)

Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in Caenorhabditis elegans
por: Denning, Daniel P., et al.
Publicado: (2013)

Novel deletion alleles of a C. elegans gene Y48E1C.1, named as tm5468, tm5625 and tm5626
por: Hori, Sayaka, et al.
Publicado: (2017)

A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis
por: Walters, Jad, et al.
Publicado: (2009)

Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model
por: Uehara, Tomoko, et al.
Publicado: (2019)

Response of G protein-coupled receptor CED-1 in germline to polystyrene nanoparticles in Caenorhabditis elegans
por: Yang, Yunhan, et al.
Publicado: (2021)

C. elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor
por: Wang, Xiaochen, et al.
Publicado: (2010)

Integration of multicopy extrachromosomal transgenes into defined loci without phenotypes
por: Yoshina, Sawako, et al.
Publicado: (2022)

CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans
por: Weaver, Benjamin P, et al.
Publicado: (2014)

Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy
por: Miyasaka, Tomohiro, et al.
Publicado: (2018)

Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans
por: Chen, Albert Tzong-Yang, et al.
Publicado: (2015)

Interaction between DLC-1 and SAO-1 facilitates CED-4 translocation during apoptosis in the Caenorhabditis elegans germline
por: Zhang, Dandan, et al.
Publicado: (2022)

Comprehensive functional genomics using Caenorhabditis elegans as a model organism
por: MITANI, Shohei
Publicado: (2017)

A Mutation in Caenorhabditis elegans NDUF-7 Activates the Mitochondrial Stress Response and Prolongs Lifespan via ROS and CED-4
por: Rauthan, Manish, et al.
Publicado: (2015)

The cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans
por: King, Skylar D., et al.
Publicado: (2018)

Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction
por: Pourkarimi, E, et al.
Publicado: (2012)

GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans
por: Yin, Jianhua, et al.
Publicado: (2017)

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation
por: Elliott, J. Michael, et al.
Publicado: (2009)

The Homologous Carboxyl-Terminal Domains of Microtubule-Associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles
por: Xie, Ce, et al.
Publicado: (2014)

Cap-Independent Translation Promotes C. elegans Germ Cell Apoptosis through Apaf-1/CED-4 in a Caspase-Dependent Mechanism
por: Contreras, Vince, et al.
Publicado: (2011)

Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons
por: Nehme, Ralda, et al.
Publicado: (2010)

Systems of Zymogen Activation
por: Milstone, J. Haskell
Publicado: (1969)

Photoexcited Enzymes for Asymmetric Csp (3)−Csp (3) Cross‐Electrophile Couplings
por: Schmidt, Sandy
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1vi0etq7qofir6at1ud6sp7cuo