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Mutation in TERT separates processivity from anchor-site function
Telomerase shows repeat-addition processivity (RAP): synthesis of multiple telomeric DNA repeats without primer dissociation. Leu14 mutants in the telomerase essential N-terminal domain of Tetrahymena thermophila telomerase reverse transcriptase retain full activity and anchor-site function but lose...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574958/ https://www.ncbi.nlm.nih.gov/pubmed/18641663 http://dx.doi.org/10.1038/nsmb.1462 |