Mutation in TERT separates processivity from anchor-site function

Telomerase shows repeat-addition processivity (RAP): synthesis of multiple telomeric DNA repeats without primer dissociation. Leu14 mutants in the telomerase essential N-terminal domain of Tetrahymena thermophila telomerase reverse transcriptase retain full activity and anchor-site function but lose...

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Detalles Bibliográficos
Autores principales: Zaug, Arthur J, Podell, Elaine R, Cech, Thomas R
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574958/
https://www.ncbi.nlm.nih.gov/pubmed/18641663
http://dx.doi.org/10.1038/nsmb.1462
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author Zaug, Arthur J
Podell, Elaine R
Cech, Thomas R
author_facet Zaug, Arthur J
Podell, Elaine R
Cech, Thomas R
author_sort Zaug, Arthur J
collection PubMed
description Telomerase shows repeat-addition processivity (RAP): synthesis of multiple telomeric DNA repeats without primer dissociation. Leu14 mutants in the telomerase essential N-terminal domain of Tetrahymena thermophila telomerase reverse transcriptase retain full activity and anchor-site function but lose RAP, suggesting models for how this domain facilitates DNA translocation.
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spelling pubmed-25749582009-02-01 Mutation in TERT separates processivity from anchor-site function Zaug, Arthur J Podell, Elaine R Cech, Thomas R Nat Struct Mol Biol Article Telomerase shows repeat-addition processivity (RAP): synthesis of multiple telomeric DNA repeats without primer dissociation. Leu14 mutants in the telomerase essential N-terminal domain of Tetrahymena thermophila telomerase reverse transcriptase retain full activity and anchor-site function but lose RAP, suggesting models for how this domain facilitates DNA translocation. 2008-07-20 2008-08 /pmc/articles/PMC2574958/ /pubmed/18641663 http://dx.doi.org/10.1038/nsmb.1462 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Zaug, Arthur J
Podell, Elaine R
Cech, Thomas R
Mutation in TERT separates processivity from anchor-site function
title Mutation in TERT separates processivity from anchor-site function
title_full Mutation in TERT separates processivity from anchor-site function
title_fullStr Mutation in TERT separates processivity from anchor-site function
title_full_unstemmed Mutation in TERT separates processivity from anchor-site function
title_short Mutation in TERT separates processivity from anchor-site function
title_sort mutation in tert separates processivity from anchor-site function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574958/
https://www.ncbi.nlm.nih.gov/pubmed/18641663
http://dx.doi.org/10.1038/nsmb.1462
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AT cechthomasr mutationintertseparatesprocessivityfromanchorsitefunction

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