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Mutation in TERT separates processivity from anchor-site function

Telomerase shows repeat-addition processivity (RAP): synthesis of multiple telomeric DNA repeats without primer dissociation. Leu14 mutants in the telomerase essential N-terminal domain of Tetrahymena thermophila telomerase reverse transcriptase retain full activity and anchor-site function but lose...

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Detalles Bibliográficos
Autores principales:	Zaug, Arthur J, Podell, Elaine R, Cech, Thomas R
Formato:	Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574958/ https://www.ncbi.nlm.nih.gov/pubmed/18641663 http://dx.doi.org/10.1038/nsmb.1462

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