Inhibitory Control Over Ca(2+) Sparks via Mechanosensitive Channels Is Disrupted in Dystrophin Deficient Muscle but Restored by Mini-Dystrophin Expression

BACKGROUND: In dystrophic skeletal muscle, osmotic stimuli somehow relieve inhibitory control of dihydropyridine receptors (DHPR) on spontaneous sarcoplasmic reticulum elementary Ca(2+) release events (ECRE) in high Ca(2+) external environments. Such ‘uncontrolled’ Ca(2+) sparks were suggested to ac...

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Detalles Bibliográficos
Autores principales: Teichmann, Martin D. H., Wegner, Frederic v., Fink, Rainer H. A., Chamberlain, Jeffrey S., Launikonis, Bradley S., Martinac, Boris, Friedrich, Oliver
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575405/
https://www.ncbi.nlm.nih.gov/pubmed/18982068
http://dx.doi.org/10.1371/journal.pone.0003644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575405/
https://www.ncbi.nlm.nih.gov/pubmed/18982068
http://dx.doi.org/10.1371/journal.pone.0003644

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