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High mobility group box-1 protein – one step closer to the clinic?
High mobility group box (HMGB)1, originally described as a nuclear protein that binds to and modifies DNA, is now regarded as a central mediator of inflammation by acting as a cytokine. HMGB1 is postulated to be particularly important as a late acting mediator of lethal septicaemia in mice. Furtherm...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575561/ https://www.ncbi.nlm.nih.gov/pubmed/18671827 http://dx.doi.org/10.1186/cc6944 |